Publications by authors named "R R Faskhutdinov"

Article Synopsis
  • Resistance to hormonal and targeted therapies in breast cancer is influenced by epigenetic alterations, particularly through DNA methylation changes linked to DNMT3A suppression.
  • The study investigates the role of NR6A1 as a regulatory factor involved in this suppression, finding that its downregulation is critical for developing resistance.
  • The research reveals that changes in cell signaling pathways and the activation of Snail, a key regulator, are associated with resistance, suggesting that the NR6A1/DNMT3A axis could help inform future breast cancer treatment strategies.
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Electromyograph unit for an automated analysis of the interference electromyogram is intended for quantitative analysis of the interference electromyogram, drawn aside by a needle electrode. The offered unit is very simple in design and allows to get the objective data of the functional state of the neuromuscular system.

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Disorders were detected in the contractile properties of tibial muscles in the patients with stroke-related motor disturbances depending on the degree of functional deficit. Maximum slow-down in the fast muscles and speeding of the slow ones was detected within half-year since the stroke.

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The subject of this experimental study was the isometric contractile properties of rat tibialis anterior muscle, number and average size of the motor units as well as type content and type-grouping of muscle fibres according to SDH activity in the same muscle after total and partial denervation (crushing the sciatic nerve and L4). It has been shown that in the process of reinnervation after total and partial denervation, quantitative differences with the general tendency in the dynamics of restoration of contractile properties of the whole muscle are found at different dynamics of restoration of electromyographic and muscle histochemical characteristics of motor units.

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