Association of Neonatal and Maternal Nasal Microbiome Among Neonates in the Intensive Care Unit.

The neonatal nasal microbiota may help protect neonates in the neonatal intensive care unit from pathogen colonization and infection. This preliminary study characterized the biodiversity of nasal microbiota comparing neonates in the neonatal intensive care unit and their mothers, highlighting the potential of strain sharing between mother-neonate pairs.

A Retrospective Case Series of Single-Screw vs Dual-Screw Fixation for Treatment of Medial Malleolus Fractures.

Background: Medial malleolus fractures (MMFs) are common across the world. Currently, there is a lack of consensus on the number of screws used in fixation of MMF. Our aim was to compare the radiographic outcomes of MMF with patients between fractures that have either undergone single-screw (SS) or dual-screw (DS) fixation.

Weathering and cementation of historic kimberlite residues from South Africa: Implications for residue stabilization and CO sequestration.

Enhanced weathering and carbon dioxide (CO) mineralization of ultramafic mine wastes, including kimberlite residues from diamond mining, provides secure storage of this greenhouse gas and may physically stabilize mine impoundments. Yet, the outcomes of these processes over extensive periods (i.e.

Progress and limitations in reactive oxygen species quantitation.

Reactive oxygen species (ROS) are a set of oxygen- and nitrogen-containing radicals. They are produced from a wide range of sources. In biological contexts, cellular stress leads to an overproduction of ROS, which can lead to genetic damage and disease development.

Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes.

Objective: Chronic inflammation and oxidative stress mediate the pathological progression of diabetic complications, like diabetic retinopathy (DR), peripheral neuropathy (DPN) and impaired wound healing. Studies have shown that treatment with a stable form of arginase 1 that reduces l-arginine levels and increases ornithine and urea limits retinal injury and improves visual function in DR. We tested the therapeutic efficacy of PEGylated arginine deiminase (ADI-PEG20) that depletes l-arginine and elevates l-citrulline on diabetic complications in the db/db mouse model of type 2 diabetes (T2D).