Publications by authors named "R R Abdrashitov"
Article Synopsis
- The RATIONALE-301 study compared the cancer treatments tislelizumab and sorafenib in adults with unresectable hepatocellular carcinoma, finding tislelizumab met the goal of noninferiority in overall survival.
- The research utilized various health-related quality of life (HRQOL) assessments and revealed that patients on tislelizumab reported better HRQOL outcomes, particularly in aspects of fatigue and physical functioning, compared to those on sorafenib.
- Overall, tislelizumab not only showed better quality of life results but also had a favorable safety profile, marking it as a promising first-line treatment option for patients with hepatocellular carcinoma.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a major cause of cancer deaths, and there is a need for new first-line treatment options; tislelizumab, a PD-1 inhibitor, shows promise as a second-line treatment.
- The RATIONALE-301 clinical trial compares the efficacy and safety of tislelizumab and sorafenib in treating unresectable HCC in newly diagnosed patients.
- Results indicate that tislelizumab meets the criteria for noninferiority in overall survival compared to sorafenib, with a median overall survival of 15.9 months vs. 14.1 months; however, it did not demonstrate superiority, while showing a higher objective response rate (14.3%
The diagnostic significance of serum markers of fibrosis was investigated in 92 patients with chronic viral hepatitis (CVH) by studying the collagenolythic activity of blood, proteasic inhibitor activity, collagen metabolism products (oxyproline fraction), and fibronectin. At the same time, the patients underwent puncture biopsy of the liver, which made it possible to determine the degree of process activity and the stage of its chronization. As the degree of fibrosis grew, the collagenase serum activity increased significantly, while the alpha1-proteinase inhibitor activity fell, the content of oxyproline (its fractions) increased, and the fibronectin level decreased.
View Article and Find Full Text PDFThe researchers evaluated the condition of lipid peroxidation and antioxidant protection system together with biochemical, immunological and morphological values in 117 patients with chronic hepatitis (CH) in virus replication phase (28 patient had CH type B, 66--CH type C and 28--CH type B+C), and estimated the importance of their interrelations to the prediction of disease outcomes.
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