Publications by authors named "R Poupon"
Background & Aims: Low-phospholipid-associated cholelithiasis (LPAC) syndrome, a rare genetic form of intrahepatic cholelithiasis in adults, is still poorly understood. We report the results of the largest-ever case-control study of patients with LPAC syndrome aiming to assess the prevalence, clinical features, and comorbidities of the disease.
Methods: We included all LPAC cases diagnosed between 2001 and 2016 in 11 French centres.
Article Synopsis
- A clinical trial investigated the effectiveness of budesonide, a corticosteroid, in patients with primary biliary cholangitis (PBC) who were not adequately responding to ursodeoxycholic acid (UDCA) treatment.
- The study included 62 patients, who were divided into two groups to receive budesonide or placebo for 36 months, but faced challenges in recruitment that limited the power of the results.
- While there were no significant improvements in liver histology, budesonide showed better outcomes in biochemical markers of liver injury compared to placebo, indicating some benefits despite not meeting the primary efficacy goal.
Background & Aims: Recurrence of primary biliary cholangitis (PBC) after liver transplantation (LT) is frequent and can impair graft and patient survival. Ursodeoxycholic acid (UDCA) is the current standard therapy for PBC. We investigated the effect of preventive exposure to UDCA on the incidence and long-term consequences of PBC recurrence after LT.
View Article and Find Full Text PDFPrimary biliary cholangitis (PBC) is an autoimmune, cholestatic, chronic liver disease that ultimately progresses towards cirrhosis and liver failure if untreated. While ursodeoxycholic acid has been established as standard of care for PBC in the last few decades, significant advances in second-line treatment options have recently been made and new therapeutic developments are currently under evaluation. The purpose of this article is to provide the clinician with an overview of the current treatment options and future opportunities for patients with PBC.
View Article and Find Full Text PDFBackground & Aims: Primary biliary cholangitis (PBC) predominantly affects middle-aged women; there are few data on disease phenotypes and outcomes of PBC in men and younger patients. We investigated whether differences in sex and/or age at the start of ursodeoxycholic acid (UDCA) treatment are associated with response to therapy, based on biochemical markers, or differences in transplant-free survival.
Methods: We performed a longitudinal retrospective study of 4355 adults in the Global PBC Study cohort, collected from 17 centers across Europe and North America.