Publications by authors named "R Pons"
Oral delivery of peptides requires formulations with high concentrations of permeation enhancer (PE) to promote absorption, and often necessitates fasting time between dosing and food ingestion. Improved formulations promoting a more rapid absorption would increase convenience of use but requires a faster onset of action. We have developed a salcaprozate-based ionic liquid (IL) formulation, namely choline salcaprozate (CHONAC), for oral delivery of a glucagon-like peptide-1 (GLP-1) analogue via gastric absorption.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluated the safety and effectiveness of reconstructing alveolar bone while removing implants due to advanced peri-implantitis in patients looking to replace failed implants for aesthetic or functional reasons.
- A mix of xenograft and autogenous bone was used along with a barrier membrane to regenerate bone, with radiographic assessments conducted before and after the procedure.
- Results showed significant improvements in alveolar ridge width and height, with a large percentage of implants maintaining health after follow-up, indicating the method is safe and effective for developing implant sites.
Bed bug infestations have been increasing worldwide since the 2000s. Their consequences for health range from skin reactions to major psychological distress. However, epidemiological data is still lacking.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how patients recovering from cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) progress with their diets postoperatively and the factors influencing this progression.* -
- Out of 42 patients, those with fast dietary progression (FDP) started a full fluid diet within 7 days, while the slow dietary progression (SDP) group took longer and faced more complications, such as prolonged ileus and longer hospital stays.* -
- The findings suggest that addressing the dietary progression speed and implementing timely nutritional strategies, such as parenteral nutrition, could improve recovery outcomes for patients with peritoneal carcinomatosis.*
Background: This work proposes the development of new vesicular systems based on anesthetic compounds (lidocaine (LID) and capsaicin (CA)) and antimicrobial agents (amino acid-based surfactants from phenylalanine), with a focus on physicochemical characterization and the evaluation of antimicrobial and cytotoxic properties.
Method: Phenylalanine surfactants were characterized via high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR). Different niosomal systems based on capsaicin, lidocaine, cationic phenylalanine surfactants, and dipalmitoyl phosphatidylcholine (DPPC) were characterized in terms of size, polydispersion index (PI), zeta potential, and encapsulation efficiency using dynamic light scattering (DLS), transmitted light microscopy (TEM), and small-angle X-ray scattering (SAXS).