Publications by authors named "R Polci"
Article Synopsis
- IgA nephropathy (IgAN) is a serious kidney disease linked to IgA buildup, and a large study identified 30 genetic risk factors associated with it.
- Fourteen new loci were discovered that suggest a connection between genetic influences and abnormal IgA levels.
- The research highlights inflammation-related pathways and potential drug targets, revealing that higher genetic risk scores are tied to earlier kidney failure.
Article Synopsis
- - The study examines how kidney pathology lesions in patients with immunoglobulin A nephropathy (IgAN) relate to long-term kidney outcomes over a follow-up of up to 35 years.
- - Key findings indicate that certain lesions (M1, S1, T1-T2) are independently linked to worsening kidney function, regardless of patient age, while specific T lesions are associated with the rate of kidney function decline.
- - Overall, the analysis shows that comprehensive pathology assessment enhances the ability to predict kidney failure risk over time, highlighting its significance in both clinical and prognostic evaluations.
The polycystic kidney disease is a genetic disease, therefore clinical features are not referred just to the affected person, but also to the other members of the family. On the other hand, the disease causes systemic involvement and it requires the contribution of different specialists such as nephrologist, geneticist, radiologist and others. Therefore, the establishment of outpatient clinics, in which a multidisciplinary team assesses the clinical features of patients belonging to the same family, is recommended.
View Article and Find Full Text PDFBackground: There is a need for early identification of children with immunoglobulin A nephropathy (IgAN) at risk of progression of kidney disease.
Methods: Data on 261 young patients [age <23 years; mean follow-up of 4.9 (range 2.