Publications by authors named "R Ploeg"
Background: In organ transplantation, cold ischemia is associated with sterile inflammation that subsequently conditions adaptive immunity directed against the grafts during revascularization. This inflammation is responsible for venous thrombosis, which is the main postoperative complication affecting graft function. Our aim was to investigate the modulation of immune responses and endothelial function of pancreatic grafts during cold ischemia using different preservation modalities.
View Article and Find Full Text PDFBackground: The clinical standard for pancreas preservation for transplantation is static cold storage (SCS). Oxygenation during preservation has been shown to be advantageous in clinical studies. This study evaluates the efficiency of different oxygenation modalities during hypothermic pancreas preservation.
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- Buruli ulcer (BU) is a skin disease caused by the bacterium Mycobacterium ulcerans, which is increasingly seen in Australia where possums serve as a reservoir for the infection.
- In a study, six wild-caught possums that had never been exposed to MU were injected and all developed BU, with ulceration occurring between 49 and 77 days after infection.
- The findings revealed systemic infection signs in most possums, indicating that this model can enhance understanding of how the bacterium spreads and can inform strategies to prevent further transmission and outbreaks.
Background: Research biopsies have great potential to advance scientific knowledge by helping to establish predictors of favourable or unfavourable outcomes in kidney transplantation. We evaluated punch and core biopsies of different sizes to determine the optimal size for clinical use.
Methods: A total of 54 punch biopsies and 18 core needle biopsies were retrieved by three transplant surgeons.