Publications by authors named "R Piske"
Microglia are the immune effector cells of the central nervous system (CNS) and react to pathologic events with a complex process including the release of nitric oxide (NO). NO is a free radical, which is toxic for all cells at high concentrations. To target an exaggerated NO release, we tested a library of 16 544 chemical compounds for their effect on lipopolysaccharide (LPS)-induced NO release in cell line and primary neonatal microglia.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the link between the angioarchitecture of brain arteriovenous malformations (bAVMs) and how they present clinically, as this relationship has been debated in the medical community.
- A total of 183 patients were reviewed, categorized by their clinical symptoms such as hemorrhage, seizure, headache, progressive neurological deficits, or incidental findings.
- Significant correlations were found, such as hemorrhage being more common in females and linked to specific angioarchitectural features, highlighting the potential for developing predictive models to identify clinical presentations based on these characteristics.*
Safety and Effectiveness of the Pipeline Flex Embolization Device With Shield Technology for the Treatment of Intracranial Aneurysms: Midterm Results From a Multicenter Study.
Neurosurgery
July 2020
Background: The safety and efficacy of the first generation of the Pipeline Embolization Device (PED; Medtronic Inc) have been proven in large case series. Ischemic events are one of the most common complications following treatment of aneurysms with flow diverters. The new PED Flex with Shield technology (PED Shield; Medtronic Inc) was introduced to minimize the rate of complications.
View Article and Find Full Text PDFObjective: Isolated dissecting spinal aneurysms are rare lesions that pose a therapeutic challenge. We report our experience in the management of four patients with dissecting spinal aneurysms.
Methods: After institutional review board approval was obtained, the neurointerventional databases of the two participating institutions were retrospectively reviewed.
Objective: The aim of this study was to describe 27 patients with 32 web vessels (WVs) from our practice and provide a review of the literature regarding imaging diagnostics, clinical presentation, and treatment of WVs.
Methods: A MEDLINE search was performed using combinations of the following terms: "stroke in young adults," "web," "recurrent stroke," "diaphragm-like," "atypical fibromuscular hyperplasia," "atypical fibromuscular dysplasia," "septal fibromuscular dysplasia," "septa," "diaphragms," "pseudovalvular folds," and "carotid diaphragm." Our series was added in this review.