Clones with 3 Ph1 and 4 Ph1 in the terminal phase of three cases of chronic myeloid leukemia.

G-banded cytogenetic studies of 3 male patients in the terminal phase of chronic myeloid leukemia showed the following abnormalities: in the first case, the presence of a medullar cell line with 51 chromosomes and 3 Ph1; in the second case, a clone with 65 chromosomes and 4 Ph1, and in the third patient a clone with 53 chromosomes and 3 Ph1. In all 3 cases, G-banding revealed the Ph1 translocation to be of the usual type: t(9;22) (q34;q11) and there was discordance between the number of Ph1 and 9q+. There was no obvious correlation between the presence of multiple Ph1 and the clinical or cytological features.

[A propos of 3 cases of Richter's syndrome].

Richter's syndrome is characterized by the association of malignant lymphoma with chronic lymphatic leukemia. Three new cases of this syndrome are reported and compared with those previously reported in the world literature. The relationship between the two lymphoid neoplasms is discussed.

Initial clinical experience with a simultaneous combination of 2,4-diamino-5(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP) with folinic acid.

DDMP, a diaminopyrimidine folate antagonist, was given to 26 tumor patients in a dosage of 50 mg/m2 per week orally, simultaneously with 3 mg CF i.m. or i.

[Triple Philadelphia chromosome during blastic crisis of a chronic myelocytic leukemia].

The blastic phase of a Ph1-positive chronic myeloid leukemia (CML) is often characterized by hyperdiploidy and sometimes by the presence of a double Ph1, suggesting a pattern of clonal evoluation. In the case reported here, the caryotype at the time of diagnosis in 1970 was 46, XY, Ph1. In 1975, after a blastic evolution followed by a drug-induced hematologic remission, cytogenetic studies revealed a chromosomal mosaic: 47, XY, 2 Ph1 and 51, XY, 3 Ph1, 3 C, the clone with 3 Ph1 representing approximately 20% of the mitotic cells.