Resilience of hierarchical actuators highlighted by a myosin-to-muscle mock-up.

Skeletal muscle is the main actuator of various families of vertebrates (mammals, fish, reptiles). It displays remarkable robustness to micro-damage, that supposedly originates both from its redundant hierarchical structure and its nervous command. A bioinspired mock-up was designed and manufactured mimicking sarcomeres (micro-scale) and its series and parallel structure from fibre to muscle.

Ontological pleasure: Exploring eating as enjoyment among people with experience of homelessness.

Amidst globally escalating housing and cost of living crises, more and more people face the double challenge of securing shelter and food in their day-to-day lives. Yet, what meanings people with experience of homelessness attribute to eating is not well understood. We analyse eating as embedded in social relations between individual actors, social institutions, and organisations.

New insights into the use of high dose corticosteroids and plasmapheresis in persons with MOGAD and NMOSD.

Background: Anti-myelin oligodendrocyte glycoprotein associated disease (MOGAD) and neuromyelitis optica spectrum disease (NMOSD) are antibody mediated diseases characterized by neurological symptoms including recurrent relapses of optic neuritis and/or myelitis, as well as other less frequent syndromes. The current treatment for acute attacks of NMOSD/MOGAD are based on clinical studies for other demyelinating diseases(i.e.

A case of restrictive dermopathy in a Hutterite newborn: Diagnosis and creative skin-directed management.

Restrictive dermopathy is a lethal autosomal recessive disease characterized by tightly adherent skin, distinctive facial dysmorphisms, arthrogryposis, and pulmonary hypoplasia. While clinical findings are unique, histopathology and genetic analysis are critical for early diagnostic confirmation and to initiate appropriate management for this lethal disease. We report on a preterm Hutterite male neonate with biallelic ZMPSTE24 mutations to highlight the clinical and histopathological features of restrictive dermopathy and share our skin-directed management strategies.

Circadian regulation of Ca 1.2 expression by RORα in the mouse heart.

Background: In addition to show autonomous beating rhythmicity, the physiological functions of the heart present daily periodic oscillations. Notably the ventricular repolarization itself varies throughout the circadian cycle which was mainly related to the periodic expression of K channels. However, the involvement of the L-type Ca channel (Ca 1.