Hybrid approach to intrapancreatic inferior pancreaticoduodenal aneurysm repair.

Pancreaticoduodenal artery aneurysms (PDAAs) are an extremely rare visceral artery aneurysm subtype, usually managed by endovascular techniques. We report the case of a 57-year-old man with an intrapancreatic, inferior PDAA abutting the superior mesenteric artery (SMA). This location, in relation to the SMA, risks SMA thrombosis using an endovascular-only approach.

Computational fluid dynamics modeling of intracranial aneurysms: qualitative comparison with cerebral angiography.

Rationale And Objective: The purpose of this study is to determine whether computational fluid dynamics modeling can correctly predict the location of the major intra-aneurysmal flow structures that can be identified by conventional angiography.

Materials And Methods: Patient-specific models of three cerebral aneurysms were constructed from three-dimensional rotational angiography images and computational fluid dynamic simulations performed. Using these velocity fields, contrast transport was simulated and visualizations constructed to provide a "virtual" angiogram.

Human embryonic stem cells and gene therapy.

Human embryonic stem cells (hESCs) theoretically represent an unlimited supply of normal differentiated cells to engineer diseased tissues to regain normal function. However, before hESCs can be useful as human therapeutics, technologies must be developed to provide them with the specific signals required to differentiate in a controlled fashion, to regulate and/or shut down the growth of hESCs and their progeny once they have been transferred to the recipient, and to circumvent the recognition of non-autologous hESC-derived cells as foreign. In the context that gene therapy technologies represent strategies to deliver biological signals to address all of these challenges, this review sets out a framework for combined gene transfer/hESC therapies.