circ_0075048 silencing regulates LCP1 to improve IL-1β-induced chondrocyte injury by binding with miR-663b.

Background: Osteoarthritis (OA) is a common type of degenerative arthropathy. Previous studies have demonstrated that circular RNAs (circRNAs) are involved in the progression of OA. This study aimed to investigate the role and associated mechanism of circ_0075048 in OA.

Precise Control of Efficient Phosphorescence in Host-Guest Doping Systems via Dynamic Metal-Ligand Coordination.

Organic room-temperature phosphorescent (RTP) materials have wide-ranging applications in anticounterfeiting, biodiagnostics, and optoelectronic devices due to their unique properties. However, it remains a challenge to give organic RTP materials dynamic tunability to satisfy the demands of various advanced applications. Herein, we propose an effective strategy to precisely modulate phosphorescent performance by incorporating dynamic metal-ligand coordination within a host-guest doped system.

The impact of different courses of osteoporotic vertebral compression fracture on the early efficacy of percutaneous vertebroplasty: a retrospective study.

Introduction: Percutaneous vertebroplasty (PVP) is a frequently employed technique for treating osteoporotic vertebral compression fracture (OVCF). However, there is still controversy regarding whether PVP with different courses affects clinical efficacy. Therefore, this study aims to investigate the impact of different courses of OVCF on early clinical and radiological outcomes after PVP.

GhRAP2.4 enhances drought tolerance by positively regulating the strigolactone receptor GhD14 expression in cotton (Gossypium hirsutum L.).

Drought poses significant challenges to crop productivity, necessitating a deeper understanding of plant adaptive mechanisms. Strigolactones (SLs), a class of phytohormones, have been recognized as crucial regulators in plant responses to drought, yet the specific role of SL receptor in drought tolerance in cotton (Gossypium hirsutum L.) remains underexplored.

Progress in Chinese medicine monomers and their nanoformulations on myocardial ischemia/reperfusion injury.

Myocardial ischemia/reperfusion injury (MIRI) is the entire process of myocardial injury resulting from ischemia and hypoxia following acute myocardial infarction, which involves complicated pathogenesis including energy metabolism disorders, calcium overload, oxidative stress and mitochondrial dysfunction. Traditional Chinese medicine (TCM) has attracted intensive attention in the treatment of MIRI owing to its multitarget therapeutic effects and low systemic toxicity. Increasing evidence indicates the promising application of TCM on the protection of cardiomyocytes, improvement of endothelial cell functions and regulation of energy metabolism and inflammatory response.