Injectable Oxygen Microparticles Boost Radiation-Mediated In Situ Vaccination and Systemic Antitumor Immune Responses.

Purpose: The aim of this work was to determine whether intratumoral injections of a liquid oxygen solution are effective at boosting radiation-induced abscopal effects.

Methods And Materials: A liquid oxygen solution, comprising slow-release polymer-shelled oxygen microparticles, was fabricated and injected intratumorally to locally elevate tumor oxygen levels before and after treatment with radiation therapy. Changes in tumor volume were monitored.

Low-Fouling Zwitterionic Polymeric Colloids as Resuscitation Fluids for Hemorrhagic Shock.

Colloids, known as volume expanders, have been used as resuscitation fluids for hypovolemic shock for decades, as they increase plasma oncotic pressure and expand intravascular volume. However, recent studies show that commonly used synthetic colloids have adverse interactions with human biological systems. In this work, a low-fouling amine(N)-oxide-based zwitterionic polymer as an alternative volume expander with improved biocompatibility and efficacy is designed.

A microfluidic device for real-time on-demand intravenous oxygen delivery.

SignificanceThe treatment of hypoxemia that is refractory to the current standard of care is time-sensitive and requires skilled caregivers and use of specialized equipment (e.g., extracorporeal membrane oxygenation).

Requirements for Building Thermal Conditions under Normal and Emergency Operations in Extreme Climates.

This paper provides recommendations on thermal and moisture parameters (air, temperature, and humidity content) in different types of buildings under normal and emergency operation conditions in extreme climate conditions, e.g., cold/arctic (U.

Metastatic cholangiocellular carcinoma and renal adenocarcinoma in a golden eagle (Aquila chrysaetos).

A 33-year-old captive male golden eagle (Aquila chrysaetos) was presented for necropsy with a history of emaciation and depression. The liver was severely distorted by numerous, coalescent, poorly demarcated, white firm nodules. Upon microscopic examination, these masses were found to be infiltrative and were composed of anastomosing tubular structures lined by signet-ring cells piling up in a disorderly fashion.