Publications by authors named "R Patejdl"
High-frequency electrical stimulation therapy (gastric electrical stimulation, GES) is a treatment option for gastroparesis of various genesis. The best indication and prognostic parameters have not yet been conclusively determined.Retrospective analysis of all gastroparesis patients implanted with a GES device between 2011 and 2020.
View Article and Find Full Text PDFArticle Synopsis
- The increase in neurogastroenterological diseases, particularly motility disorders, is significant among the aging population, impacting various parts of the GI tract from swallowing to fecal incontinence.
- Evidence shows that while basic GI function remains largely intact with aging, there is a notable rise in conditions like constipation and fecal incontinence, especially among elderly women.
- Research suggests that these motility disorders in older adults may stem from factors like a decline in cholinergic neurons and changes in GI-specific cells and immune responses, compounded by existing chronic diseases.
Background: The diagnosis of intensive care unit (ICU)-acquired weakness (ICUAW) and critical illness neuromyopathy (CINM) is frequently hampered in the clinical routine. We evaluated a novel panel of blood-based inflammatory, neuromuscular, and neurovascular biomarkers as an alternative diagnostic approach for ICUAW and CINM.
Methods: Patients admitted to the ICU with a Sequential Organ Failure Assessment score of ≥ 8 on 3 consecutive days within the first 5 days as well as healthy controls were enrolled.
Intensive care unit-acquired weakness (ICUAW) is one of the most common causes of muscle atrophy and functional disability in critically ill intensive care patients. Clinical examination, manual muscle strength testing and monitoring are frequently hampered by sedation, delirium and cognitive impairment. Many different attempts have been made to evaluate alternative compliance-independent methods, such as muscle biopsies, nerve conduction studies, electromyography and serum biomarkers.
View Article and Find Full Text PDFMitochondria are key structures providing most of the energy needed to maintain homeostasis. They are the main source of adenosine triphosphate (ATP), participate in glucose, lipid and amino acid metabolism, store calcium and are integral components in various intracellular signaling cascades. However, due to their crucial role in cellular integrity, mitochondrial damage and dysregulation in the context of critical illness can severely impair organ function, leading to energetic crisis and organ failure.
View Article and Find Full Text PDF