Publications by authors named "R Pascale"
Introduction: Infections significantly impact morbidity and mortality in lung transplant (LuTx) recipients. This survey focused on documenting current practices regarding the prevention and management of infections in LuTx in Italy.
Methods: A 52-question survey was administered online in the period from December 1, 2023, to January 31, 2024, assessing center characteristics, Tx team organization, microbiological investigations, infection prevention, and management.
Cardiac implantable electronic devices infections (CIEDI) are associated with poor survival despite the improvement in transvenous lead extraction (TLE). Aetiology and systemic involvement are driving factors of clinical outcomes. The aim of this study was to explore their contribute on overall mortality.
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- Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive liver cancer with poor treatment options, prompting research into new therapies targeting the Heat Shock Factor 1 (HSF1) transcription factor.
- Studies showed that HSF1 levels are significantly elevated in various stages of iCCA and correlate with worse patient outcomes, while inhibiting HSF1 delayed tumor development in mouse models.
- The HSF1 inhibitor KRIBB-11 was effective in slowing iCCA cell growth, inducing cell death, and reducing key metabolic functions in cancer cells, highlighting its potential as a therapeutic avenue.
Article Synopsis
- The study investigates the impact of adequate empirical combination therapy (AECT) on 30-day mortality rates in septic shock patients infected with Pseudomonas aeruginosa.
- Of 98 patients analyzed, those receiving AECT had a significantly lower mortality rate (25%) compared to those on adequate empirical monotherapy (AEMT) (56.8%), indicating AECT may enhance survival.
- The findings suggest transitioning to a single effective antibiotic after confirming susceptibility is safe, highlighting the need for further research to validate these results.
Article Synopsis
- A study on perioperative antibiotic prophylaxis (PAP) in lung transplant recipients over a 20-year period revealed significant variation in practices among different centers.
- The research enrolled 111 lung transplant recipients, finding that most received combination therapy, while the median duration for PAP was 10 days.
- However, the study concluded that there was no significant difference in preventing early post-operative infections (EPOIs) between combination and single-agent therapies, and duration of PAP also did not impact EPOI rates.