A Conjugated Polymer-Based Portable Smartphone Platform for Sensitive and Point-Of-Care Detection of Monoamine Neurotransmitter.

The precise and effective detection of neurotransmitters (NTs) is crucial for clinical investigation of neuronal processes, and timely monitoring of NT-related chronic diseases. However, sensitive detection of specific NT with unprecedented selectivity is highly challenging due to similarities in chemical and electronic structures of various interfering neurochemicals. Herein, an anionic conjugated polyelectrolyte Poly[(9,9-bis(4'-sulfonatobutyl)fluorene-co-alt-1,4-phenylene) sodium], PFPS was rationally designed and synthesized for amplified detection and point-of-care (PoC) determination of monoamine neurotransmitter, serotonin (5-Hydroxy tryptamine or 5-HT, also diagnostic biomarker of carcinoid tumor) in human blood plasma.

Aggregation induced bright organic luminogens: Design strategies, advanced bio-imaging and theranostic applications.

The concept of aggregation-induced emission (AIE) in purely organic luminescent molecules has drawn wide attention in the last two decades. Despite the many challenges, AIE-probes have opened versatile opportunities in many research fields. In particular, the emerging functional properties of room temperature phosphorescence (RTP) and thermally activated delayed fluorescence (TADF) have boosted the unique features of AIE luminogens (AIEgens).

Dual "Static and Dynamic" Fluorescence Quenching Mechanisms Based Detection of TNT via a Cationic Conjugated Polymer.

A rare combination of dual static and dynamic fluorescence quenching mechanisms is reported, while sensing the nitroexplosive trinitrotoluene (TNT) in water by a cationic conjugated copolymer PFPy. Since the fluorophore PFPy interacts with TNT in both ground state as well as the excited states, a greater extent of interaction is facilitated between PFPy and the TNT, as a result of which the magnitude of the signal is amplified remarkably. The existence of these collective sensing mechanisms provides additional advantages to the sensing process and enhances the sensing parameters, such as LoD and highly competitive sensing processes in natural water bodies irrespective of the pH and at ambient conditions.

RETRACTED: Anisotropic (spherical/hexagon/cube) silver nanoparticle embedded magnetic carbon nanosphere as platform for designing of tramadol imprinted polymer.

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