Publications by authors named "R Paredis"
Study Question: Can recurrent embryo developmental problems after ICSI be overcome by assisted oocyte activation (AOA)?
Summary Answer: AOA did not improve blastocyst formation in our patient cohort with recurrent embryo developmental problems after ICSI.
What Is Known Already: The use of AOA to artificially induce calcium (Ca2+) rises by using Ca2+ ionophores (mainly calcimycin and ionomycin) has been reported as very effective in overcoming fertilization failure after ICSI, especially in patients whose Ca2+ dynamics during fertilization are deficient. However, there is only scarce and contradictory literature on the use of AOA to overcome embryo developmental problems after ICSI, and it is not clear whether abnormal Ca2+ patterns during fertilization disturb human preimplantation embryo development.