FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregnancy - protocol for a prospective multicentre mixed-methods feasibility study.

Introduction: Selective fetal growth restriction (sFGR) in monochorionic twin pregnancy, defined as an estimated fetal weight (EFW) of one twin <10th centile and EFW discordance ≥25%, is associated with stillbirth and neurodisability for both twins. The condition poses unique management difficulties: on the one hand, continuation of the pregnancy carries a risk of death of the smaller twin, with a high risk of co-twin demise (40%) or co-twin neurological sequelae (30%). On the other, early delivery to prevent the death of the smaller twin may expose the larger twin to prematurity, with the associated risks of long-term physical, emotional and financial costs from neurodisability, such as cerebral palsy.

Diagnosis and management of selective fetal growth restriction in monochorionic twin pregnancies: A cross-sectional international survey.

Objective: To identify current practices in the management of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies.

Design: Cross-sectional survey.

Setting: International.

Role of Thymoquinone on sleep restriction and its mitigating effect on leptin-mediated signaling pathway in rat brain.

Background: Sleep and stress interact bidirectionally by acting on brain circuits that affect metabolism. Sleep and its alterations have impact on blood leptin levels, metabolic hormone that regulates appetite. Brain expresses the receptors for the peptide hormone leptin produced from adipocytes.

Exploration-Exploitation Tradeoff in the Adaptive Information Sampling of Unknown Spatial Fields with Mobile Robots.

Adaptive information-sampling approaches enable efficient selection of mobile robots' waypoints through which the accurate sensing and mapping of a physical process, such as the radiation or field intensity, can be obtained. A key parameter in the informative sampling objective function could be optimized balance the need to explore new information where the uncertainty is very high and to exploit the data sampled so far, with which a great deal of the underlying spatial fields can be obtained, such as the source locations or modalities of the physical process. However, works in the literature have either assumed the robot's energy is unconstrained or used a homogeneous availability of energy capacity among different robots.