Publications by authors named "R Parana"
Article Synopsis
- A comprehensive study analyzed 468 cases of idiosyncratic drug-induced liver injury (DILI) in Latin America over a decade, revealing key demographic details such as a predominance of women (62%) and a mean age of 49 years.
- The analysis found that hepatocellular injury was the most common (62%), with significant occurrences of jaundice (60%) and hospitalization (42%), while 4.1% of cases resulted in fatal outcomes.
- The study highlights a rising incidence of liver injuries linked to herbal and dietary supplements, as well as specific drugs like nimesulide and nitrofurantoin, suggesting the need for public health initiatives to educate on the risks associated with these medications.
Introduction: Data on positive rechallenge in idiosyncratic drug-induced liver injury (DILI) are scarce. We aim to analyse the clinical presentation, outcome and drugs associated with positive rechallenge in two DILI registries.
Methods: Cases from the Spanish and Latin American DILI registries were included.
Article Synopsis
- Idiosyncratic drug-induced liver injury (DILI) with DRESS is less understood in Western countries, but a study identified 53 cases from Spanish and Latin American registries to analyze their clinical characteristics and outcomes.
- Patients with DILI-DRESS were generally younger and exhibited more frequent cholestatic or mixed liver damage compared to a larger group of DILI patients, with only one case progressing to acute liver failure and resulting in death.
- The study found that certain medications, particularly anti-epileptics like carbamazepine and lamotrigine, were more commonly associated with DILI-DRESS, and higher bilirubin levels and lack of eosinophilia were linked to worse health outcomes.
Systemic Inflammatory Molecules Are Associated with Advanced Fibrosis in Patients from Brazil Infected with Hepatitis Delta Virus Genotype 3 (HDV-3).
Microorganisms
May 2023
Background And Aims: Hepatitis Delta virus (HDV) genotype 3 is responsible for outbreaks of fulminant hepatitis in Northeastern South America. This study investigates if systemic inflammatory molecules are differentially expressed in patients with advanced fibrosis chronically infected with Hepatitis Delta virusgenotype 3(HDV-3).
Methods: Sixty-one patients from the north of Brazil coinfected with hepatitis B virus (HBV)/HDV-3 were analyzed.
Background & Aims: Idiosyncratic drug-induced liver injury (DILI) with autoimmune features is a liver condition with laboratory and histological characteristics similar to those of idiopathic autoimmune hepatitis (AIH), which despite being increasingly reported, remains largely undefined. We aimed to describe in-depth the features of this entity in a large series of patients from two prospective DILI registries.
Methods: DILI cases with autoimmune features collected in the Spanish DILI Registry and the Latin American DILI Network were compared with DILI patients without autoimmune features and with an independent cohort of patients with AIH.