Multiple-dose pharmacokinetics of ceftibuten after oral administration to healthy volunteers.

The pharmacokinetics of ceftibuten in plasma and urine were investigated after oral administration. Twelve healthy subjects were treated orally twice daily with 400 mg of the drug for 7 days; on day 8, the subjects received a last dose of 400 mg of ceftibuten. Ceftibuten and its metabolite, the trans isomer of ceftibuten, were assayed in plasma and urine by a specific HPLC method with UV detection.

[Late sequelae of severe injuries to the viscerocranium: clinical, radiographic and CT findings].

After 1 to 7 years the late results of the surgical treatment of 21 patients with partly severe viscerocranial fractures have been evaluated by means of clinical as well as radiographic and CT examinations (with special thin sections and reconstructions). In demonstrating fractures and hemorrhages or mucosal swelling in the sinuses CT was found to be superior--except for fractures of the floor of the orbita and the nasal bone. Clinical dysfunctions and disorders included among others impaired eye motility (5), optic nerve lesions (2), bone prominences (14; predominantly at the orbital margins, in one case resulting in severe deformity of the face), dental and functional masticatory disorders (10), sinus problems and headache (11).

Intramyocardial distribution of hydroquinidine in the dog.

Hydroquinidine concentrations were measured simultaneously in the plasma and in right atrial and ventricular biopsy samples of four dogs in the steady state after eight days of oral sustained release hydroquinidine administration. The right ventricular concentrations were greater than the plasma concentrations in all samples (ratio 5.02(2.

Vascular structure enhances regional resistance responses in mild essential hypertension.

Forearm blood flow (FABF) and forearm vascular resistance (FAVR) responses to sequential regional infusions of norepinephrine (NE) and angiotensin II (Ang II) were examined in 24 hypertensive and 18 matched normotensive subjects. Sensitivity to both vasoconstrictors, defined as the percentage increase in FAVR in response to the lowest dose of each agonist, was similar in the two groups. Also, the FABF response curve to the full range of both agonists did not differ between hypertensives and normotensives by analysis of variance (ANOVA).