A controlled trial of adinazolam versus desipramine in geriatric depression.

Thirty outpatients between the ages of 60 and 85 with DSM-III Major Depression entered an 8 week randomized, double-blind comparison of desipramine and adinazolam mesylate, a triazolobenzodiazepine derivative. Outcome was assessed on several measures including the Hamilton Depression Rating Scale (HDRS), Montgomery-Asberg Rating Scale, Clinical Global Impressions (CGI), the 35-item Self-Rating Symptom Scale, and Carroll Depression Scale. Patients in both groups demonstrated a highly significant decrease in average HDRS scores (p less than 0.

A comparison of nefazodone, imipramine, and placebo in patients with moderate to severe depression.

In this sample of moderately to severely depressed outpatients, nefazodone therapy proved superior to placebo. Nefazodone therapy was also associated with fewer dropouts from adverse effects than was imipramine. In view of these efficacy findings as well as the promising side effect and safety profile of nefazodone, further research is warranted to evaluate its therapeutic potential in the treatment of depressive illness.

Concurrent diagnostic validity of a structured psychiatric interview.

In order to estimate the concurrent validity of a structured psychiatric interview, we compared interview diagnoses obtained for 101 psychiatric inpatients to those recorded in the same patients' hospital charts. For most diagnoses considered, concordance was found to be high. For those in which concordance was low, we examined the reasons for the diagnostic discrepancy.

Reliability of psychiatric diagnosis. II. The test/retest reliability of diagnostic classification.

In a study of interrater diagnostic reliability, 101 psychiatric inpatients were independently interviewed by physicians using a structured interview. Newly admitted patients were randomly selected and examined by one of three psychiatrists. A second psychiatrist reexamined the same patient about 24 hours later.