Publications by authors named "R Palacios-Diaz"
Vitiligo-like hypopigmentation secondary to adjuvant checkpoint inhibitor therapy in patients with resectable stage III melanoma: a cohort from two tertiary hospitals.
Melanoma Res
January 2025
Vitiligo-like hypopigmentation induced by immune checkpoint inhibitors (ICIs) has been largely associated with improved survival outcomes in metastatic melanoma. However, its development during adjuvant ICI therapy and its role as a prognostic factor in this setting remain unclear. We aimed to describe ICI-induced vitiligo in a cohort of patients with resected stage III melanoma treated with adjuvant ICI and to identify differences in progression-free survival (PFS) and distant metastasis-free survival (DMFS) between those who developed vitiligo and those who did not.
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- The study investigates microsatellite instability (MSI) in melanoma patients by examining the expression of DNA mismatch repair (MMR) proteins in tissue samples, which is important for understanding its prognostic value and treatment strategies.* -
- Out of 93 melanoma patients, most showed significant expression of MMR proteins, but a low expression of MSH6 and overall MMR protein expression (MMR-e) was linked to better melanoma-specific survival rates.* -
- The findings suggest that patients with higher MMR-e who received immunotherapy experienced worse outcomes, indicating the need for further research to clarify the implications of MSI in melanoma treatments.*
Megaconial congenital muscular dystrophy (MCMD) is a rare autosomal-recessive multisystem disorder characterized by delayed motor development, intellectual disability, and skin involvement. We report a patient with MCMD who had diffuse ichthyosis-like scaling, and successfully responded to ustekinumab.
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