IL-6, IL-10 and TNF-α gene polymorphisms in preeclampsia: a case-control study in a Mexican population.

Objectives: We focused our study on examining the genotype and allele frequency of IL-6 (rs1800795), TNF-α (rs1800629) and IL-10 (rs1800872) single nucleotide polymorphisms (SNP) on preeclampsia (PE) diagnosed Mexican pregnant women.

Material And Methods: A case-control study was designed including 86 preeclampsia patients and 100 normotensives pregnancies from Women's Hospital of Culiacan, Mexico. Genotyping of IL-6, TNF-α and IL-10 was performed using TaqMan SNP Genotyping.

Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy.

Despite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to has already been established in different populations worldwide. In this study, we investigated the possible association of the HLA-DRB1 alleles with leprosy in a Mexican Mestizo population.

[« Double flag » flap nipple reconstruction. Clinical evaluation on 70 cases].

Background: Since 2004, we have chosen a nipple reconstruction with a "double flag" local flap. We have retrospectively assessed its results in the long term and identified the factors likely to influence them.

Methods: Seventy reconstructions have been analyzed through a subjective study and objective one through measures of size and the projection of the nipple.

Non sentinel node involvement prediction for sentinel node micrometastases in breast cancer: nomogram validation and comparison with other models.

Purpose: The risk of non sentinel node (NSN) involvement varies in function of the characteristics of sentinel nodes (SN) and primary tumor. Our aim was to determine and validate a statistical tool (a nomogram) able to predict the risk of NSN involvement in case of SN micro or sub-micrometastasis of breast cancer. We have compared this monogram with other models described in the literature.

Kinetics of HER2/neu ECD in 45 patients treated with trastuzumab (Herceptin) between January 2001 and June 2005 at the Grenoble University Hospital.

Unlabelled: The aim of this study was to evaluate the utility of HER2/neu ECD concentration as a marker of the efficacity of clinical response to Herceptin.

Patients And Methods: Iterative measurements of HER2/neu ECD (ELISA c-erbB2/c-neu Rapid Format Elisa kit QIA10 Calbiochem) concentrations in 45 patients treated with Herceptin between January 2001 and June 2005 at the Grenoble University Hospital.

Results: Changes in HER2/neu ECD concentrations were observed in 21 patients (47%).