Publications by authors named "R P Turankar"
Leprosy is a disease with spectral clinical manifestations along with two types of reactions, type 1 reaction (T1R) and type 2 reaction (T2R). T1R especially occurs because of the defensive upgradation of cell-mediated immunity (CMI) to antigens. T1R is the main cause of disability in leprosy.
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- Leprosy is caused by two bacteria, Mycobacterium leprae and Mycobacterium lepromatosis, which can't be easily grown in labs. This study focused on detecting M. lepromatosis in patients with various forms of leprosy, particularly those with type 2 reactions (ENL).
- The research involved 75 multibacillary leprosy patients and used specific DNA extraction and sequencing techniques to confirm the presence of M. lepromatosis in their samples.
- Results showed M. lepromatosis in four necrotic ENL patients, with varying levels of genetic similarity to known strains, and specific proteins from the bacteria were identified, supporting its role in leprosy cases studied
Article Synopsis
- In regions where leprosy is endemic, new cases are still being reported, indicating that the prevalence has not decreased to levels that would qualify as elimination.
- A study was conducted to assess the viability of Mycobacterium leprae in patients undergoing a 12-month treatment of multidrug therapy, aiming to understand how this affects disease transmission.
- Out of 78 initial cases, results showed that a significant number retained viable bacteria even after completing the treatment, suggesting that they had active lesions and could still contribute to the spread of the disease.
Objectives: Purulia is one of the high-endemic districts for leprosy in West Bengal (the eastern part of India). The annual new case detection rate (ANCDR) of leprosy in West Bengal is 6.04/100000 (DGHS 2019-20).
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