Search for optimal scheme for administering live allantoic influenza vaccine.

The effect of vaccine dilution and composition on indices of vaccination activity was studied in a live allantoic influenza vaccine administered intranasally to adults. The vaccine was shown to be usable in a 1:1 (instead of 1:5) dilution without risk of its reactogenicity rising. An inhibition of component A(H3N2) was observed in a bivalent vaccine obtained by combining directly before use two monovalent vaccines, A(H1N1) and A(H3N2).

Effectiveness of peroral and intranasal immunization of school children with live allantoic influenza vaccine- and comparative study.

A comparative study of two preparations of allantoic live influenza vaccine, one for intranasal and the other for peroral immunization of children of school age, was peformed under conditions of a blind epidemiological trial. Previously obtained data on the safety and high immunogenicity of the intranasal vaccine variant, prepared from extremely attenuated cold-adapted strains, were confirmed. The peroral administration of the live influenza vaccine, in use in the USSR for active immunization of the adult population, also stimulated influenza immunity without producing postvaccinal reactions.