Publications by authors named "R P Rouhl"
Objective: The objective of this study was to explore the financial consequences of adopting cenobamate as a treatment alternative in epilepsy patients with drug-resistant focal onset seizures (FOS) from a societal perspective in the Netherlands.
Methods: A previous budget impact model with a 5-year time horizon was adapted to the Dutch setting accounting for the eligible population, real-world market shares, treatment effectiveness and resource use in two scenarios: cenobamate with constant market share versus cenobamate with linearly increased market share up to 20%. Clinical inputs included treatment response, seizure reduction and adverse events.
Introduction: Anti-GABABR encephalitis is a rare disease reported to be often associated with tumors. The current study aims to summarize the clinical characteristics, imaging features, treatments, outcomes and explore the potential prognosis risk factors of patients with anti-GABABR encephalitis.
Methods: Patients tested positive for anti-GABABR were retrospective studied from a single medical center in China over a period of 3 years.
During ongoing narratives, event boundaries trigger processes relevant for subsequent memory. Previous work has shown that novel, unrelated input presented at an event boundary can retroactively interfere with short-term retention of the preceding event. This interference was attributed to a perturbation of offset-related processes taking place within seconds after encoding and supporting the binding of elements into a coherent event memory.
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- Aggression is a major issue in society, particularly among neuropsychiatric patients, but its underlying neural mechanisms and treatment options remain unclear.
- Researchers analyzed data from 182 Vietnam War veterans with head injuries to identify a specific brain network linked to aggression, finding a key hub in the right prefrontal cortex and other connected regions.
- The study suggests that targeting this aggression-associated brain circuit through neuromodulation methods, like deep brain stimulation, could be a potential therapeutic approach for managing aggression-related symptoms.
Article Synopsis
- The study investigated the risk of acute symptomatic seizures in patients who experience recurrent strokes compared to those having their first stroke, looking at data from stroke patients over a 5-year period.
- The findings revealed that the risk of seizures was similar for both groups, with 5.1% for recurrent stroke patients and 4.5% for first-time patients, suggesting prior stroke history doesn’t increase seizure risk.
- Other factors like age, sex, and hemorrhagic changes were linked to seizures only in first-time stroke patients, indicating different risk profiles between the two groups; further research in larger studies is encouraged to validate these results.