Publications by authors named "R P Rapini"
Front Immunol
October 2024
Article Synopsis
- The study focuses on the effects of pertussis toxin (PTx) from Bordetella pertussis and its potential to induce autoimmune responses in mice, specifically examining its interaction with myelin oligodendrocyte peptide (MOG).
- Mice administered PTx and MOG didn't develop experimental autoimmune encephalomyelitis (EAE) but exhibited patchy alopecia in 36.4% of cases, linked to immune system changes around hair follicles.
- Histological analysis confirmed alopecia areata characteristics, showing a disruption of hair follicle immune privilege and increased immune cell activity, highlighting a potential connection between PTx exposure and immune system disorders.
