[Experimental data on the toxicity of nonachlazine, a new antianginal agent].

The results obtained by a study of acute and chronic toxicity of nonachlazine--a new original coronary-active agent endowed with antianginal properties are reported. Nonachlazine has been found to have a sufficiently wide range of therapeutic action. With its repeated (for 36 days) oral introduction to rats in an effective dose of 10 mg/kg the drug does not produce any adverse effect on the general condition of the animals, reduces but insignificantly their weight gain, fails to exert any damaging effect on the blood system, does not change biochemical characteristics featuring the function of the liver, nor evokes any pathohistological changes of the internal organs.

[Intracellular mechanism of the action of imipramine and diazepam].

The content of noradrenaline during the action of antidepressant imipramine and a tranquilizer diazepam was determined in rats by differential centrifugation of the hypothalamus tissues. Imipramine was found to decrease the noradrenaline content in synaptosomes, whereas diazepam failed to evoke any similar effects. Thus, in the action mechanism of the first substance the adrenergic compound was of definite importance, while in the mechanism of the second one it took no part.