Single versus two dental implants retained mandibular over dentures: comparison of function, patient satisfaction, oral health-related quality of life and success of treatment.

Objective: To compare the effectiveness of prosthetic rehabilitation of edentulous patients using conventional complete dentures (CD), single median dental implant retained over dentures (SIMOD) with over dentures retained by two dental implants (TIMOD).

Methods: Thirty completely edentulous patients (fifteen each arm) presented to the Faculty of Dental Sciences, University of Peradeniya were randomly selected for the SIMOD or TIMOD groups. Patients were initially provided with CD.

Elevated cardiac troponin secondary to heterophile antibodies: a case series highlighting an underrecognized differential.

Background: Heterophile antibody presence confounds troponin assay results, causing falsely elevated troponin levels. This rare phenomenon is an important differential to consider when evaluating patients with suspected acute coronary syndrome. We present a case series of three patients with similar clinical presentations where the presence of heterophile antibodies was confirmed.

Diabetic Retinopathy and Periodontitis: Implications from a Systematic Review and Meta-Analysis.

Background: Diabetes mellitus, a chronic metabolic disorder affecting millions worldwide, is associated with microvascular complications, including diabetic retinopathy (DR) and periodontitis. Understanding their interrelationship is crucial for comprehensive patient care.

Objective: This systematic review and meta-analysis aim to investigate the association between DR and periodontitis in patients with Type 1 and Type 2 diabetes.

Itacitinib for Prevention of Graft-Versus-Host Disease and Cytokine Release Syndrome in Haploidentical Transplantation.

Haploidentical hematopoietic cell transplantation (haplo-HCT) is an increasingly used treatment for hematologic malignancies. Although post-transplant cyclophosphamide (PtCy) has improved graft vs. host disease (GvHD) prophylaxis in haplo-HCT, patients continue to experience life-threatening complications.

Reducing heart failure deaths by 25% in 25 years: the '25in25' heart failure summit.

Heart failure (HF) is a major cause of morbidity and mortality in older people, and 80% of people with HF are aged over 60 years. HF is the end point for almost all common cardiovascular diseases, as well as many non-cardiovascular diseases. Despite this, HF remains underdetected and undertreated.