Publications by authors named "R P Pollis"
Ketosis-prone Diabetes Presenting with Acute Esophageal Necrosis or "Black Esophagus": An Intriguing New Clinical Association.
Endocr Metab Immune Disord Drug Targets
June 2024
Background: Ketosis-prone diabetes (KPD) is an intermediate subtype of diabetes mellitus, usually affecting Afro-American adults, presenting with diabetic ketoacidosis (DKA), without the classic phenotype of autoimmune type 1 diabetes. Patients require insulin therapy at onset for the acute decompensation, then usually remain insulin-free for prolonged periods with diet alone or with other antidiabetic drugs. DKA can be rarely complicated by upper gastrointestinal bleeding and mucosal necrosis, a severe complication named acute esophageal necrosis (AEN) burdened by high mortality.
View Article and Find Full Text PDFAim: We examined whether metabolic dysfunction-associated steatotic liver disease (MASLD) with or without significant fibrosis (assessed by validated non-invasive biomarkers) was associated with an increased risk of prevalent chronic kidney disease (CKD) or diabetic retinopathy in people with type 1 diabetes mellitus (T1DM).
Methods: We performed a retrospective multicenter cross-sectional study involving 1,409 adult outpatients with T1DM, in whom hepatic steatosis index (HSI) and fibrosis (FIB)-4 index were calculated for non-invasively detecting hepatic steatosis (defined by HSI > 36), with or without coexisting significant fibrosis (FIB-4 index ≥ 1.3 or < 1.
Association between different modalities of insulin administration and metabolic dysfunction-associated fatty liver disease in adults with type 1 diabetes mellitus.
Diabetes Metab
November 2023
Article Synopsis
- - This study aimed to compare the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in adults with type 1 diabetes using either multiple daily injections (MDI) or insulin pumps (CSII).
- - Researchers analyzed data from 1,417 individuals, finding that insulin pump users tended to be younger, had better blood sugar control, and a lower prevalence of MAFLD with significant liver fibrosis compared to those on MDI.
- - The results suggested that while insulin pump therapy was linked to a lower risk of MAFLD with significant fibrosis, this association largely disappeared after adjusting for factors like age and blood sugar levels.
Hepatic steatosis with significant fibrosis is associated with an increased 10-year estimated risk of cardiovascular disease in adults with type 1 diabetes mellitus.
Cardiovasc Diabetol
August 2023
Background: We assessed whether hepatic steatosis with or without significant fibrosis (determined by validated non-invasive biomarkers) is associated with an increased 10-year estimated risk for cardiovascular disease (CVD) in people with type 1 diabetes mellitus (T1DM).
Methods: We conducted a retrospective, multicenter, cross-sectional study involving 1,254 adults with established T1DM without pre-existing CVD. We used the hepatic steatosis index (HSI) and fibrosis (FIB)-4 index for non-invasively detecting hepatic steatosis (defined as HSI > 36), with or without coexisting significant fibrosis (defined as FIB-4 index ≥ 1.
Ketosis-prone Diabetes and Hypogonadism: A New Clinical Association to be Aware of ?
Endocr Metab Immune Disord Drug Targets
September 2023
Article Synopsis
- Ketosis-prone diabetes (KPD) is a new form of diabetes that shares characteristics of both type 1 and type 2 diabetes, commonly seen in African American adults who experience diabetic ketoacidosis but may later achieve insulin-free remission.
- The text presents two cases of young African patients with KPD, one affected by Klinefelter's syndrome and the other by primary ovarian failure, both managed effectively with insulin and oral medications.
- The study emphasizes the need for better recognition of KPD and suggests that evaluating sex hormones at diabetes onset could provide insights into its associations with conditions like hypogonadism, warranting further exploration of hormonal influences on KPD.*