Publications by authors named "R P Pauly"
Home Sweet Home: A Program Report on Promoting the Uptake of Home Dialysis.
Can J Kidney Health Dis
January 2025
Purpose Of Program: Canada's growing prevalence of people with kidney failure receiving kidney replacement therapy has necessitated the expansion of dialysis programs. Although facility-based hemodialysis is the predominant dialysis modality in Canada, it is substantially costlier than home dialysis (peritoneal or home hemodialysis). Initiatives to increase the uptake of home dialysis typically consist of didactic and experiential education.
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- PhenoMetaboDiff is an innovative R package designed for analyzing and visualizing data from Biolog Phenotype Mammalian Microarrays, which study the energy production of mammalian cells under various conditions.* -
- It provides non-parametric statistical methods, integrates with the OPM package for file conversion, calculates performance metrics like slope and area under the curve, and includes visualization tools to analyze specific metabolic pathways.* -
- This package enhances the assessment of metabolic profiles and is user-friendly, making advanced analysis accessible for both experienced and beginner R users, ultimately benefiting research in various disease conditions.*
Objectives: Ramadan fasting is an Islamic religious practice involving abstinence from food and drink from dawn to sunset. Its consequences on kidney-relevant outcomes in patients with chronic kidney disease (CKD) and kidney transplant recipients remain unclear.
Design: Systematic review and meta-analysis.
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a very dangerous cancer that doesn't respond well to treatment, and doctors have been using a drug called gemcitabine for over 30 years to try and help patients.
- Scientists studied 28 patient samples to see how their bodies reacted to gemcitabine and to find out why some patients develop resistance to the drug.
- They discovered specific gene patterns related to the cancer's energy processes could predict how well patients would respond to gemcitabine, and they found that certain mutations in a gene called TP53 were linked to treatment resistance.
Homo sapiens and Neanderthals underwent hybridization during the Middle/Upper Paleolithic age, culminating in retention of small amounts of Neanderthal-derived DNA in the modern human genome. In the current study, we address the potential roles Neanderthal single nucleotide polymorphisms (SNP) may be playing in autism susceptibility in samples of black non-Hispanic, white Hispanic, and white non-Hispanic people using data from the Simons Foundation Powering Autism Research (SPARK), Genotype-Tissue Expression (GTEx), and 1000 Genomes (1000G) databases. We have discovered that rare variants are significantly enriched in autistic probands compared to race-matched controls.
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