Publications by authors named "R P Maĭ"
The pre-metastatic niche constructed by cancer-associated fibroblasts (CAFs) plays a key role in the hypoxic tumor microenvironment (TME), promoting hepatocellular carcinoma (HCC) metastasis. Integrin, which is involved in cell-to-cell or cell-to-matrix interactions and TME regulation, affects tumor metastasis. However, the complex interactions between integrin-mediated HCC cells and CAFs remain unclear.
View Article and Find Full Text PDFThis study aims to explore the mechanism underlying the role of ubiquitin-specific protease 14 (USP14) in regulating P53 expression and influencing the development of hepatitis B. The animal and cell models of hepatitis B were constructed. The mRNA and protein expression of USP14, mouse double minute 2 (MDM2), and P53 were detected by western blot and qPCR.
View Article and Find Full Text PDFObjective: Stereoelectroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) is an invasive procedure based on stereotactic lesioning of cortical targets in the brain using bipolar current through electrode contacts within the SEEG implant. To date, several RF-TC protocols have been described in the literature; however, a consensus has yet to be reached. This work aims to analyze the electrical parameters during RF-TC processes, offering a method to objectively describe and compare different SEEG-guided RF-TC protocols.
View Article and Find Full Text PDFArticle Synopsis
- * Analysis of clinical data from 2018 to 2023 revealed a 22.0% infection rate, with the majority of cases occurring in young children, especially between June and September; Serogroup B and Typhimurium were the most common isolated strains.
- * The findings indicate an increasing drug resistance, particularly to ceftriaxone, with Typhimurium showing higher multi-drug resistance; continuous surveillance and proper antibiotic use are essential to address this issue effectively.
Article Synopsis
- The study examined the monocyte-to-lymphocyte ratio (MLR) as a potential predictor of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) who had curative surgery between 2018 and 2023.
- In a sample of 196 patients, preoperative MLR was found to be a more effective indicator of overall survival (OS) and disease-free survival (DFS) than other inflammation-based scores and tumor markers.
- Results showed that patients with high MLR had significantly worse OS and DFS compared to those with low MLR, highlighting MLR as an independent risk factor for patient outcomes.