Publications by authors named "R P M Julie"
Patient and Public Involvement in Pharmacoepidemiological Research: An Environmental Scan of an Emerging Area.
Pharmacoepidemiol Drug Saf
January 2025
Background: Patient and public involvement (PPI) in research is required to improve the relevance, feasibility, and interpretability. However, research on PPIs in pharmacoepidemiology (PE) is still limited. This study aimed to provide an overview of PPI implementation in pharmacoepidemiology through an environmental scan.
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- Antibody-drug conjugates (ADCs) are a promising targeted cancer treatment, but none have been approved specifically for colorectal cancer (CRC) yet.
- LGR4/5/6 receptors are commonly found in CRC, and while ADCs targeting LGR5 show strong anti-tumor effects, not all CRC cells express LGR5, leading to challenges.
- A new drug conjugate, R462-CPT2, combines a modified RSPO4 protein with a potent drug and has displayed effective anti-tumor activity in CRC models without significant side effects, making it a strong candidate for CRC therapy.
The Galactic Centre contains a supermassive black hole with a mass of four million Suns within an environment that differs markedly from that of the Galactic disk. Although the black hole is essentially quiescent in the broader context of active galactic nuclei, X-ray observations have provided evidence for energetic outbursts from its surroundings. Also, although the levels of star formation in the Galactic Centre have been approximately constant over the past few hundred million years, there is evidence of increased short-duration bursts, strongly influenced by the interaction of the black hole with the enhanced gas density present within the ring-like central molecular zone at Galactic longitude |l| < 0.
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