Publications by authors named "R P Lloubes"
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Filamentous phages are nonlytic viruses that specifically infect bacteria, establishing a persistent association with their host. The phage particle has no machinery for generating energy and parasitizes its host's existing structures in order to cross the bacterial envelope and deliver its genetic material. The import of filamentous phages across the bacterial periplasmic space requires some of the components of a macrocomplex of the envelope known as the Tol system.
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- The TonB-ExbB-ExbD molecular motor converts the proton motive force to help transport essential nutrients into bacteria by linking the inner and outer membranes.
- Recent research revealed the first high-resolution structure of the ExbB-ExbD complex, identifying five ExbB proteins surrounding a single ExbD, although earlier findings suggested two ExbD copies.
- Using cryo-electron microscopy, the study clarified that the ExbB pentamer actually contains a dimer of ExbD, which changes our understanding of how this motor functions.
During cell division, gram-negative bacteria must coordinate inner-membrane invagination, peptidoglycan synthesis and cleavage and outer-membrane (OM) constriction. The OM constriction remains largely enigmatic, and the nature of this process, passive or active, is under debate. The proton-motive force-dependent Tol-Pal system performs a network of interactions within these three compartments.
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