LXRα agonists ameliorates acute rejection after liver transplantation via ABCA1/MAPK and PI3K/AKT/mTOR signaling axis in macrophages.

Introduction: Liver X receptor α (LXRα) plays an important role in inflammatory immune response induced by hepatic ischemia-reperfusion injury (IRI) and acute rejection (AR). Macrophage M1-polarization play an important role in the occurrence and development of AR. Although the activation of LXR has anti-inflammatory effects, the role of LXRα in AR after liver transplantation (LT) has not been elucidated.

Synergistic effect of RuNi alloy supported by carbon nanohorns for boosted hydrogen evolution from ammonia borane hydrolysis.

The present study addresses the critical challenges associated with hydrogen production from ammonia borane (AB) hydrolysis, focusing on the development of cost-effective, high efficient, and stable catalysts. A promising strategy to achieve superior catalytic performance in AB hydrolysis involves alloying noble and non-precious metals. Herein, RuNi bimetallic nanoparticles were successfully deposited onto carbon nanohorns (CNHs) through a facial hydrothermal-reduction processes.

Incidence and mortality related risk factors in patients with severe traumatic brain injury: A meta‑analysis.

The present study aimed to clarify the onset of traumatic brain injury (TBI) and identify mortality-related risk factors in patients with severe TBI, to enable the early identification of high-risk individuals and timely implementation of prevention and treatment strategies to minimize mortality rates. Comprehensive database searches were conducted across Web of Science, PubMed, CINAHL and EMBASE, covering publications from database inception until October 17, 2023. Search terms in English included 'head trauma', 'brain trauma', 'mortality', 'death' and 'risk factor'.

Solvation-mediated adsorption mechanism of solvated lithium ions at a charged solid-liquid interface for electrochemical energy storage: atomic scale investigation and insights.

Ion encapsulation by solvent molecules significantly impacts ion transport and the adsorption mechanism in energy storage devices. The aim of this investigation is to analyse the adsorption mechanisms associated with the solvation shell of lithium ions near the electrode/electrolyte interface during the charging process. Simulations using molecular dynamics (MD) are conducted for LiPF salt in PC solvent confined in between two flat carbon electrodes.

The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation.

The proper assembly and maturation of collagens necessitate the orchestrated hydroxylation and glycosylation of multiple lysyl residues in procollagen chains. Dysfunctions in this multistep modification process can lead to severe collagen-associated diseases. To elucidate the coordination of lysyl processing activities, we determine the cryo-EM structures of the enzyme complex formed by LH3/PLOD3 and GLT25D1/ColGalT1, designated as the KOGG complex.