Publications by authors named "R P Keegan"
Florbetaben (FBB) is a radiopharmaceutical approved by the FDA and EMA in 2014 for the positron emission tomography (PET) imaging of brain amyloid deposition in patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) or other causes of cognitive decline. Initially, the clinical adoption of FBB PET faced significant barriers, including reimbursement challenges and uncertainties regarding its integration into diagnostic clinical practice. This review examines the progress made in overcoming these obstacles and describes the concurrent evolution of the diagnostic landscape.
View Article and Find Full Text PDFBackground: Patient's clinical characteristics, technical resources, center and operator volume, and operator experience and training are known variables impacting outcomes. Although international standards have been agreed to maximize the benefits of this therapy, regional and global differences still exist. Latin American information has not been updated in the last 10 years.
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- - Regular participation in sports is beneficial for physical and mental health, but some sports environments may contribute to mental health issues among participants.
- - Elite sports organizations have guidelines for psychological safety, but these do not always apply to recreational sports, leading to a demand for specific mental health guidelines in that context.
- - A study using the Delphi technique gathered insights from 21 experts to identify key areas for mental health guidelines in community sports, resulting in 13 statements focused on promoting positive mental health and clarifying the roles of community sport organizations and governance.
Background Understanding health professional perceptions and experiences when supporting post-stroke physical activity may assist with development of strategies targeting low physical activity observed in this group. The aims of this study were to explore health professionals' perceptions and experiences of post-stroke physical activity, the barriers they experience and potential facilitators when supporting people with stroke to be active. Methods Ten focus groups were conducted with 57 health professionals (physiotherapists, occupational therapists, nurses, exercise physiologists, psychologists and sports scientists) and allied health students.
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- * A new validation method identifies register errors by comparing actual residue contacts and distances in structural models to those predicted by systems like AlphaFold2, offering corrections that often improve refinement statistics.
- * This approach is different from traditional methods as it is not reliant on stereochemistry or resolution, and it identifies potential issues in PDB entries, aiding in the accuracy of future deposits.