Publications by authors named "R P J Budde"
Background: Trials comparing non-vitamin K oral anticoagulant (NOAC) versus antiplatelet-based strategies have shown a reduction of subclinical leaflet thrombosis at the cost of increased mortality and major-bleedings. NOACs were often combined with antiplatelet therapy.
Aims: The Rotterdam Edoxaban (REDOX) study aimed to evaluate the impact of edoxaban monotherapy on the incidence of hypo-attenuated leaflet thickening (HALT) and reduced leaflet motion (RLM) and to evaluate safety in terms of mortality, thromboembolic events and major bleeding.
Background: Transcatheter mitral valve replacement (TMVR) is emerging in the context of annular calcification (valve-in-MAC; ViMAC), failing surgical mitral annuloplasty (mitral-valve-in-ring; MViR) and failing mitral bioprosthesis (mitral-valve-in-valve; MViV). A notorious risk of TMVR is neo left ventricular outflow tract (neo-LVOT) obstruction. Three-dimensional computational models (3DCM) are derived from multi-slice computed tomography (MSCT) and aim to predict neo-LVOT area after TMVR.
View Article and Find Full Text PDFDiagnostic performance of high and ultra-high-resolution photon counting CT for detection of coronary artery disease in patients evaluated for transcatheter aortic valve implantation.
Int J Cardiovasc Imaging
November 2024
Article Synopsis
- - The study evaluated the effectiveness of ultra-high-resolution (UHR) and high-resolution (HR) modes of photon-counting detector CT scans for diagnosing coronary artery disease (CAD) in 60 patients before TAVI procedures, using quantitative coronary angiography (QCA) as a standard reference.
- - Patients were divided into three groups based on the scanning mode used: HR mode, UHR mode, and an adjusted UHR mode designed for better coronary imaging, which included modifications in tube voltage and image quality.
- - Results showed that UHR and adjusted UHR modes had improved sensitivity and negative predictive values for detecting CAD, but statistically, there were no significant differences compared to the HR mode in terms of diagnostic performance.
Article Synopsis
- The study aimed to assess how often clinically relevant extracardiac findings occur during cardiac CT and MRI exams across various patient demographics and examination reasons.
- The analysis included over 200,000 cardiac CT scans and over 228,000 cardiac MRI scans, revealing extracardiac findings in 3.28% of CT exams and 1.50% of MRI exams, with higher rates associated with specific procedures like transcatheter aortic valve replacement.
- Older patients showed a significant increase in the prevalence of these findings, emphasizing the importance of age and examination purpose in assessing patient outcomes.
Background And Aims: Abdominal aortic aneurysm (AAA) patients undergo uniform imaging surveillance until reaching the surgical threshold. In spite of the ongoing exploration of AAA pathophysiology, biomarkers for personalized surveillance are lacking. This study aims to identify potential circulating biomarkers for AAA growth on serial CT scans.
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