Publications by authors named "R P Hurst"
Weed management is an essential intervention for maintaining food security and protecting biodiversity but is heavily reliant on chemical control measures (, herbicides). Concerningly, only one herbicide has been developed with a new mode of action (MOA) since the 1980s. Therefore, alternative strategies for preventing weed growth need to be explored.
View Article and Find Full Text PDFArticle Synopsis
- - The study examined the use of the modified pouchitis disease activity index (mPDAI) to assess symptoms and endoscopic findings among different pouchitis phenotypes in inflammatory bowel disease (IBD).
- - A total of 103 IBD patients were analyzed, revealing that patients with normal pouches had a median mPDAI of 0, while those with cuffitis had the highest median score of 4.0, indicating more severe symptoms.
- - The findings suggested that the mPDAI may have limited effectiveness in differentiating between various inflammatory phenotypes, prompting the need for further research to identify which symptoms should be monitored.
Nontuberculous mycobacterial pulmonary disease (NTM-PD) results from opportunistic lung infections by mycobacteria other than or species. Similar to many other countries, the incidence of NTM-PD in the United Kingdom (UK) is on the rise for reasons that are yet to be determined. Despite guidelines established by the American Thoracic Society (ATS), the Infectious Diseases Society of America, and the British Thoracic Society, NTM-PD diagnosis and management remain a significant clinical challenge.
View Article and Find Full Text PDFBackground: Patients with inflammatory bowel disease (IBD) who undergo proctocolectomy with ileal pouch-anal anastomosis may develop pouchitis. We previously proposed a novel endoscopic classification of pouchitis describing 7 phenotypes with differing outcomes. This study assessed phenotype transitions over time.
View Article and Find Full Text PDFProstate cancer is the most common non-cutaneous cancer among men in the UK, causing significant health and economic burdens. Diagnosis and risk prognostication can be challenging due to the genetic and clinical heterogeneity of prostate cancer as well as uncertainties in our knowledge of the underlying biology and natural history of disease development. Urinary extracellular vesicles (EVs) are microscopic, lipid bilayer defined particles released by cells that carry a variety of molecular cargoes including nucleic acids, proteins and other molecules.
View Article and Find Full Text PDF