Publications by authors named "R P Hickerson"
A tensioned ex vivo full-thickness human skin explant platform was used to assess the bioeffects arising from application of several commercial chemexfoliation agents. Although such treatments are well-established, and improved understanding of the underlying mechanistic processes continues to emerge, research into the optimum treatments for specific skin types/conditions is still needed for enhanced efficacy while minimizing recovery time. The 3 commercial chemexfoliation agents employed all contained trichloroacetic acid at well-defined concentrations (6, 10, and 20%) and were applied to the explants' stratum corneum.
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- Pachyonychia congenita (PC) is a rare genetic disorder characterized by abnormal skin cornification and is inherited in a dominant fashion.
- It has attracted significant research attention over the past 20 years, largely due to efforts from the Pachyonychia Congenita Project, a patient support organization.
- The article discusses ongoing research in PC, potential benefits for managing other diseases, and challenges facing these initiatives.
Epidermolysis bullosa is a group of genetic skin conditions characterized by abnormal skin (and mucosal) fragility caused by pathogenic variants in various genes. The disease severity ranges from early childhood mortality in the most severe types to occasional acral blistering in the mildest types. The subtype and severity of EB is linked to the gene involved and the specific variants in that gene, which also determine its mode of inheritance.
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