Publications by authors named "R P Hearn"
Article Synopsis
- The study compares the real-world effectiveness and safety of three treatments for atopic dermatitis: dupilumab, ciclosporin (CyA), and methotrexate (MTX), using data from the A-STAR register in the UK and Ireland.
- It involved 488 patients (adults and children) and measured treatment outcomes like the Eczema Area and Severity Index (EASI) and quality of life scales over 12 months.
- Results showed that dupilumab and CyA led to faster improvements in skin severity scores and overall patient outcomes compared to MTX, indicating dupilumab is an effective option in managing atopic dermatitis.
Objective: The objective was to investigate the effectiveness of a person-centred active rehabilitation programme on symptoms associated with suspected Chronic Traumatic Encephalopathy (CTE). This was accomplished by (1) assessing the effect that a person-centred active rehabilitation programme had on participant symptoms, and (2) exploring how temporal contextual factors affected the participants' experience with, and perceived effectiveness of, the active rehabilitation programme.
Methods: A twelve-month mixed-methods single case experimental research design was used with six cases (participants).
Article Synopsis
- A study compared the safety and effectiveness of ciclosporin (CyA) and methotrexate (MTX) in treating severe atopic dermatitis (AD) in children and young people aged 2-16 who didn't respond to topical treatments.
- Cyclists showed more significant improvement at the 12-week mark, with more patients achieving at least a 50% improvement in their AD scores compared to those on MTX.
- However, by the 60-week follow-up, MTX demonstrated better long-term outcomes, indicating its potential superiority beyond the initial treatment period.