Publications by authors named "R P H Raijmakers"
With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research. More than 95% of FDA-approved drugs currently target proteins, and most diagnostic tests are protein-based. The introduction of proteomics to the clinic, for instance to guide patient stratification and treatment, is already ongoing.
View Article and Find Full Text PDFArticle Synopsis
- - The management of chronic lymphocytic leukemia (CLL) is evolving due to new therapies and advancements in treatment options, prompting a revision of Dutch guidelines.
- - The updated guidelines from the HOVON CLL working group emphasize evidence from clinical trials, focusing on factors like efficacy, toxicity, treatment duration, and intensity.
- - The article offers recommendations on diagnosing CLL, treatment strategies for both newly diagnosed and relapsed patients, and supportive care for complications related to the disease, tailored to current treatment availability in the Netherlands.
Consensus on timing of post-hematopoietic stem cell transplantation (HSCT) vaccination is currently lacking and is therefore assessed in this review. PubMed was searched systematically for articles concerning vaccination post-HSCT and included a basis in predefined criteria. To enable comparison, data were extracted and tables were constructed per vaccine, displaying vaccine response as either seroprotection or seroconversion for allogeneic HSCT (alloHSCT) and autologous HSCT (autoHSCT) separately.
View Article and Find Full Text PDF