Aeromedical evacuation-relevant hypobaria following traumatic brain injury in rats contributes to cerebral blood flow depression, altered neurochemistry, and increased neuroinflammation.

Aircraft cabins are routinely pressurized to the equivalent of 8000 ft altitude. Exposure of lab animals to aeromedical evacuation relevant hypobaria after traumatic brain injury worsens neurological outcomes, which is paradoxically exacerbated by hyperoxia. This study tested the hypothesis that exposure of rats to hypobaria following cortical impact reduces cerebral blood flow, increases neuroinflammation, and alters brain neurochemistry.

Generative Artificial Intelligence in Pathology and Medicine: A Deeper Dive.

This review article builds upon the introductory piece in our 7-part series, delving deeper into the transformative potential of generative artificial intelligence (Gen AI) in pathology and medicine. The article explores the applications of Gen AI models in pathology and medicine, including the use of custom chatbots for diagnostic report generation, synthetic image synthesis for training new models, data set augmentation, hypothetical scenario generation for educational purposes, and the use of multimodal along with multiagent models. This article also provides an overview of the common categories within Gen AI models, discussing open-source and closed-source models, as well as specific examples of popular models such as GPT-4, Llama, Mistral, DALL-E, Stable Diffusion, and their associated frameworks (eg, transformers, generative adversarial networks, diffusion-based neural networks), along with their limitations and challenges, especially within the medical domain.

Harnessing the Power of Generative Artificial Intelligence in Pathology Education: Opportunities, Challenges, and Future Directions.

Context.—: Generative artificial intelligence (AI) technologies are rapidly transforming numerous fields, including pathology, and hold significant potential to revolutionize educational approaches.

Objective.

Evaluating combined effects of chronic, low-dose exposures of cadmium (CLEC) and hyperglycemia on insulin signaling dysfunction in a hepatocellular model.

The pathophysiological effects of chronic heavy metal exposures on human health remains uncertain. In this study, we developed a novel chronic, low-dose exposure of Cadmium (CLEC) model using the hepatocellular cell lines, HepG2 and HUH7. We modulated cell culture conditions to mimic human normoglycemic (5.