The Chimeric Peptide (GEP44) Reduces Body Weight, Energy Intake, and Energy Expenditure in Diet-Induced Obese Rats.

We recently reported that a chimeric peptide (GEP44) targeting the glucagon-like peptide-1 receptor (GLP-1R) and neuropeptide Y1- and Y2-receptors decreased body weight (BW), energy intake and core temperature in diet-induced obese (DIO) male and female mice. Given that GEP44 was found to reduce core temperature (surrogate measure of energy expenditure (EE)) in DIO mice, we hypothesized that GEP44 would reduce EE in male and female high fat diet (HFD)-fed rats. To test this, rats were maintained on a HFD for at least 4 months to elicit DIO prior to undergoing a sequential 2-day vehicle period, 2-day GEP44 (50 nmol/kg) period and a minimum 2-day washout period and detailed measures of energy homeostasis.

Elucidating the impact of low DO on enhanced biological phosphorus removal under aerobic and anoxic conditions at full-scale.

Research on low dissolved oxygen (DO) enhanced biological phosphorus removal (EBPR) at full-scale remains limited, a knowledge gap this study aims to fill by investigating EBPR performance and microbial community shifts at a Water Resource Recovery Facility (WRRF) transitioning to low DO conditions. Average DO concentrations decreased from 2.62 mg O/L in 2019 to 0.

Improved Uptake of Vaccinations in Children With Adverse Events Following Immunization After Specialist Immunization Service Intervention in an Australian Pediatric Hospital.

Background: Adverse Events Following Immunization (AEFI) have significant implications for public health, potentially leading to decreased immunization rates and vaccine hesitancy. Understanding the characteristics and outcomes of children experiencing AEFI is crucial for effective intervention strategies and informed decision-making. This study aimed to describe the diverse range of AEFI presentations, identify common referral sources and assess factors influencing vaccination uptake following specialist consultation.

Implant waste and associated costs in trauma and orthopaedic surgery: a systematic review.

Purpose: Trauma and orthopaedic (T&O) surgery relies on medical implants and materials, often resulting in metalwork wastage (prosthesis, screws, nails, and plates). This places an economic strain on healthcare services and the environment. Our primary outcome is to quantify the implant wastage across the literature, and secondarily investigate the associated costs in this specialty.

Should formalities be less formal? A comparative study of patient preferences on formalities and accommodation choices from 1999 to 2023.

Purpose: To explore if patients' preferences regarding formalities and inpatient accommodation during their inpatient hospital experience have changed since 1999.

Methods: A ten-item survey was administered to an inpatient sample in an urban teaching hospital and compared with results from a similar survey in 1999.

Results: The majority (98.