Publications by authors named "R P Daniele"
Background: Assessing urinary symptoms poses a complex challenge for primary care practitioners. In evaluating urological function, our approach involves constructing an urological age through the analysis of laboratory parameters and indicators of the urinary system.
Methods: Based on the National Health and Nutrition Examination Survey (NHANES), urological laboratory tests and age-related symptoms were included in the development of urological age (UA) and urological age acceleration (UAA) through the Klemera Doubal method.
Article Synopsis
- - The study investigated the prevalence of alcohol abuse and lifestyle habits such as smoking in psoriasis patients undergoing various treatments, including biological therapies.
- - Out of 305 patients, 18% were identified as being at high risk for alcohol abuse, with a higher occurrence of serious psoriasis types in that group.
- - Despite findings that alcohol abuse was common, it did not significantly affect the effectiveness of biological treatments for psoriasis, nor did it impact medication adherence rates.
Hodgkin lymphoma (HL) is among the most commonly occurring malignancies in adolescents. For relapsed/refractory disease, many regimens have been proposed. Novel agents are increasingly used, like brentuximab vedotin (BV), an antiCD30 antibody-drug conjugate, used as a single agent or in combination with classic regimens mainly in adults, while limited is the experience in pediatrics.
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- - Nutritional status significantly impacts mortality rates in pediatric oncology patients, yet current practices for assessing their nutritional needs are inconsistent across Italy.
- - A nationwide survey of 21 pediatric oncology centers revealed that only half routinely assessed all patients and used a variety of clinical and biochemical measures for evaluation.
- - The study highlights the urgent need for standardized guidelines to improve nutritional care and outcomes for pediatric cancer patients, given the variability in existing practices.
The cell interaction, mechanism of cell entry and intracellular fate of surface decorated nanoparticles are known to be affected by the surface density of targeting agents. However, the correlation between nanoparticles multivalency and kinetics of the cell uptake process and disposition of intracellular compartments is complicated and dependent on a number of physicochemical and biological parameters, including the ligand, nanoparticle composition and colloidal properties, features of targeted cells, etc. Here, we have carried out an in-depth investigation on the impact of increasing folic acid density on the kinetic uptake process and endocytic route of folate (FA)-targeted fluorescently labelled gold nanoparticles (AuNPs).
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