Coassembly of Cell-Penetrating Peptide Octaarginine with Acetazolamide: Emergent Interactions with .

The investigation of established pharmaceutical agents for recalibrating usage strongly supplements new drug development. In this work, we have prepared coassembled complexes of acetazolamide (AZM) with the cationic peptide octaarginine (R8) in an attempt to enhance its potency and scope of use. R8 and AZM in different weight ratios coassemble into remarkable nano- and microstructures such as ribbons, sheets, and stick-like structures.

Tunable Coassembly of Octaarginine with Thiazolyl Benzenesulfonamides Exerts Variable Antibacterial Activity.

The cationic peptide octaarginine (R8) is a prominent cell-penetrating peptide and has been extensively researched as a carrier of diverse cell-destined cargo. In this work, we describe the coassembly of R8 with small molecule thiazolyl benzenesulfonamide (TBS) derivatives. Physical complexation of R8 with three TBS derivatives across a range of weight ratios results in the formation of a distinctive set of nano- and microstructures.

Robust Rain-Repellency and Droplet Bouncing Properties of Fresh and Aged Leaves Up to 6 Months.

Robust rain-repellent surfaces are useful in roofs, solar panels, windshields, etc. Herein, excellent rain-repellency and droplet bouncing properties of leaves are presented. They possess surface microbumps ( ∼ 13 μm, ∼ 8 μm, ∼ 3 μm), which in turn comprise nanoplatelets ( ∼ 741 nm, ∼ 59 nm) and Wenzel roughness ( ) of ∼2.

Outcome of Endovascular and Open Treated Penetrating Aortic Ulcers.

Purpose: Penetrating aortic ulcer (PAU) is a rare etiology of acute aortic syndrome. Few studies exist regarding the perioperative outcome. The aim was to analyze clinical outcome and risk factors of mortality in this treatment population.