Evaluating temperature dynamics: a single-center prospective randomized pilot study of holmium versus thulium laser fiber for renal stones.

Background: We aimed to evaluate and compare the rise in the temperature for the safety of the kidney parenchyma on firing the Holmium: Yttrium Aluminium Garnet laser and the Thulium Fiber Laser during laser lithotripsy in humans.

Method: We included 30 pre-stented patients with renal calculi undergoing Retrograde intra-renal surgery. They were randomized into two groups - 15 patients underwent holmium laser lithotripsy and 15 patients underwent TFL laser lithotripsy.

Comparison of Temperature Changes Between Holmium-YAG Laser and Thulium Fiber Laser in an In Vitro Setting.

Objective: We aimed to evaluate and compare the rise in the temperature for the safety of the ureter and kidney parenchyma when firing the holmium laser and the thulium fiber laser (TFL).

Methods: We performed a laboratory experiment to measure the rise in temperature upon firing holmium laser and a TFL in a 10 cm3 transparent test tube in an outdoor environment and then in a container with normal saline.

Results: In a 10 cc test tube with static water at 25°C, the rise in temperature with holmium and TFL depends on the firing time, keeping power constant.

Recurrent Subdural and Epidural Hematomas: A Case Report of Complications Following Craniotomy and Middle Meningeal Artery Embolization.

This report presents a 76-year-old male patient who developed indolent right-sided upper and lower extremity weakness and low back pain following a fall that resulted in no trauma and was not prompted by syncope or vertigo. Imaging revealed a chronic subdural hematoma (cSDH) with midline shift, for which the patient underwent craniotomy and middle meningeal artery (MMA) embolization. Despite initial intervention, the patient experienced rare and severe complications, including the recurrence of a subdural hematoma (SDH), the development of an epidural hematoma, and frontal lobe herniation.

Maximising efficacy in HER2-positive breast cancer: immunoliposomal co-delivery of miR155 inhibitor and paclitaxel for targeted therapy.

Breast cancer, particularly the HER2 positive subtype, presents a formidable challenge in clinical oncology, necessitating innovative therapeutic strategies. Here, we present a novel immunoliposome-based formulation designed for targeted delivery of paclitaxel and miRNA inhibitors to HER2-positive breast cancer cells. Through a rigorous preclinical evaluation encompassing cellular studies and an tumor xenograft model, we demonstrate the formulation's remarkable efficacy in inhibiting cell proliferation, inducing apoptosis, and suppressing tumor growth.

Tobacco use, cirrhosis, and age are predictors of readiness to change and continued drinking following brief alcohol intervention in veterans.

Alcohol use disorder is prevalent within the Veterans Health System, especially in patients being seen in hepatology clinics, and needs a point-of-care strategy. A brief alcohol intervention based on AUDIT-C (Alcohol Use Disorders Identification Test) may be needed for the management of hazardous alcohol intake, but feasibility is unclear. We aimed to define predictors of readiness to cease alcohol intake (0-10, 10 being ready to quit now) and continued drinking after using a brief alcohol intervention in veterans seen in hepatology clinics cross-sectionally and longitudinally over 6 months.