Publications by authors named "R P Chappell"
Objectives: Alterations in the tumor suppressor TP53 gene are the most common mutations in high grade serous ovarian carcinoma. The impact of TP53 mutations on clinical outcomes and platinum resistance is controversial. We sought to evaluate the genomic profile of high grade serous ovarian carcinoma and explore the association of TP53 mutations with platinum resistance.
View Article and Find Full Text PDFArticle Synopsis
- Published norms typically miss early cognitive changes linked to dementia, prompting the development of new standards using data from two Alzheimer's risk cohorts.
- The research utilized quantitative regression to create both cross-sectional and longitudinal normative standards based on data from nearly 1,400 cognitively healthy participants over an average of 9 years.
- Findings indicate that lower percentile scores correlate with cognitive impairment and higher Alzheimer’s biomarker levels, while a ShinyApp was created to help visualize scores and identify low performance.
Introduction: We assessed whether midlife sensory and motor functions added to prediction models using the Cardiovascular Risk Factors, Aging, and Incidence of Dementia Score (CAIDE) and Framingham Risk Score (FRS) improve risk predictions of 10-year changes in biomarkers of neurodegeneration and Alzheimer's disease.
Methods: Longitudinal data of = 1529 (mean age 49years) Beaver Dam Offspring Study participants from baseline, 5-year, and 10-year follow-up were included. We tested whether including baseline sensory (hearing, vision, olfactory) impairment and motor function measures improves CAIDE or FRS risk predictions of 10-year incidence of biomarker positivity of serum-based neurofilament light chain (NfL) and amyloid beta (Aβ)/Aβ using logistic regression.
Article Synopsis
- The study aimed to identify risk factors linked to brain aging and sensory decline in older adults (aged 64-100), involving 1,478 participants.
- Factors associated with increased brain aging included not drinking alcohol, high interleukin-6 levels, depressive symptoms, and a history of stroke, while higher education was protective.
- The findings suggest that addressing shared risk factors could enhance neurological function and improve the quality of life for older adults.
Purpose: To determine whether 4-dimensional computed tomography (4DCT) ventilation-based functional lung avoidance radiation therapy preserves pulmonary function compared with standard radiation therapy for non-small cell lung cancer (NSCLC).
Methods And Materials: This single center, randomized, phase 2 trial enrolled patients with NSCLC receiving curative intent radiation therapy with either stereotactic body radiation therapy or conventionally fractionated radiation therapy between 2016 and 2022. Patients were randomized 1:1 to standard of care radiation therapy or functional lung avoidance radiation therapy.