Publications by authors named "R P Byington"
Background: Whereas there exists a direct relationship between glycated hemoglobin and cardiovascular disease (CVD), clinical trials targeting glycated hemoglobin to near-normal levels using intensive therapy have failed to prevent CVD and have even increased mortality, making clinical decision making difficult. A common polymorphism at the haptoglobin (Hp) genetic locus is associated with CVD, especially coronary heart disease, in the setting of hyperglycemia.
Objectives: This study sought to determine whether the treatment difference of intensive versus standard glucose-lowering therapy on risk of CVD events in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) study depended on Hp phenotype.
Importance: Patients with type 2 diabetes are at high risk of cardiovascular disease (CVD) in part owing to hypertriglyceridemia and low high-density lipoprotein cholesterol. It is unknown whether adding triglyceride-lowering treatment to statin reduces this risk.
Objective: To determine whether fenofibrate reduces CVD risk in statin-treated patients with type 2 diabetes.
In this chapter, we build on the scholarship on youth civic engagement by turning attention to the environmental commons as a space for political action. We begin with a definition of the term and arguments about ways that social justice is implied in it. Following that, we raise several psychological challenges to motivating action on behalf of the environmental commons and discuss the critical experiences and actions that can defy those challenges.
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- Intensive blood pressure (BP) lowering (systolic BP <120 mm Hg) was found to significantly reduce the risk of left ventricular hypertrophy (LVH) in patients with diabetes compared to standard BP lowering (systolic BP <140 mm Hg).
- After a median follow-up of 4.4 years, intensive BP treatment resulted in a 39% lower risk of developing LVH and a notable reduction in the Cornell index, which measures LVH.
- The findings suggest that achieving lower BP targets can stabilize or reverse heart damage in hypertensive diabetes patients, regardless of age, sex, or race.
Background And Objectives: High levels of fibroblast growth factor 23 are associated with accelerated progression of CKD. Whether high fibroblast growth factor 23 levels also predict incident CKD is uncertain.
Design, Setting, Participants, & Measurements: A prospective case-cohort study was conducted within the Action to Control Cardiovascular Risk in Diabetes Trial.