Publications by authors named "R P Bernard"

Article Synopsis
  • Mechanical thrombectomy is a common treatment for ischemic strokes, but sedation during the procedure can cause agitation in patients.
  • This study, part of the AMETIS research, evaluated patients who experienced agitation and found that 38% had at least one episode during the procedure.
  • Although agitation didn’t significantly affect thrombolysis scores or overall outcomes, it did correlate with a higher need for intubation and poorer radiological image quality.
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Article Synopsis
  • A highly sensitive LC-MS/MS method was developed to measure total and unbound doravirine in plasma from patients in a clinical trial, utilizing a single calibration curve for both forms of the drug.
  • The method involved protein precipitation for total doravirine extraction and ultrafiltration for unbound doravirine, employing specific chromatography techniques to ensure accurate analysis.
  • Validation tests confirmed the method's precision and robustness against various sample conditions, meeting international standards for effective quantification of doravirine concentrations.
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The molecular diagnosis of type 1 facioscapulohumeral muscular dystrophy (FSHD1) relies on the detection of a shortened D4Z4 array at the 4q35 locus. Until recently, the diagnosis of FSHD2 relied solely on the absence of a shortened D4Z4 allele in clinically affected patients. It is now established that most FSHD2 cases carry a heterozygous variant in the SMCHD1 gene.

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Colonization by Clostridioides difficile is common in children with inflammatory bowel disease (IBD) and complicates both the management of IBD and the diagnosis of C. difficile infection (CDI). There is a paucity of data on rates, risk factors, and outcomes associated with asymptomatic C.

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Background: The use of mobile technology to meet health needs, widely referred to as mobile health (mHealth), has played a critical role in providing self-management support for chronic health conditions. However, despite its potential benefits, mHealth technologies such as self-management support apps for spinal cord injury (SCI) have received little research attention, and an understanding of their public availability is lacking. Therefore, an overview of these apps is needed to complement findings from the literature for a complete understanding of mHealth self-management support tools for SCI to support the selection and improvement of existing apps and the development of new ones.

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