Publications by authors named "R P Barnwal"
Pre-mRNA processing in eukaryotes involves capping, splicing, cleavage, and polyadenylation. Various proteins regulating this key transcriptional event in humans share considerable homology with proteins. Among these proteins, Pcf11 is a crucial component of the yeast CF IA sub-unit, and Ydh1 is part of the CPF sub-unit.
View Article and Find Full Text PDFThe cleavage and polyadenylation step are indispensable for pre-mRNA processing in eukaryotes. Defective 3'- end maturation of precursor mRNA has catastrophic effects, leading to several diseases in humans. This processing is orchestrated by a complex machinery comprising more than 20 proteins in .
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- Neural tube defects (NTDs) are a major congenital issue in India, but there is limited data on their prevalence across different regions of the country.
- This meta-analysis reviewed literature on NTDs from various databases up to October 2023, finding a prevalence of 9.46 per 1000 births and significant regional differences.
- The study emphasizes the rising trend of NTDs and calls for urgent preventive measures, including public awareness, antenatal screening, and nutritional interventions like folic acid supplementation.
Breast cancer is one of the leading causes of death among women globally, making its diagnosis and treatment challenging. The use of nanotechnology for cancer diagnosis and treatment is an emerging area of research. To address this issue, multiwalled carbon nanotubes (MWCNTs) were ligand exchanged with butyric acid (BA) to gain hydrophilic character.
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- - The study focused on postmenopausal osteoporosis (PMO) and type 2 diabetes mellitus (T2DM), examining how these conditions coexist in postmenopausal women through proton nuclear magnetic resonance (H NMR) metabolomics.
- - Researchers analyzed serum samples from 80 women across different groups, discovering significant metabolic profile differences, especially in the T2DM + PMO group, which displayed elevated levels of various metabolites linked to lipid metabolism and energy processes.
- - The findings identified alanine as a key metabolic biomarker that could help distinguish between the conditions and provide insights into their underlying mechanisms, highlighting alanine's potential as an early diagnostic marker for these health issues.